Peptide therapy Weight and metabolism
Retatrutide / Cagrilintide
What it is and what people take it for, in plain language.
What is Retatrutide / Cagrilintide?
Next-generation metabolic peptides: retatrutide acts on three hormone receptors (GLP-1, GIP and glucagon); cagrilintide is an amylin analog, studied mainly together with semaglutide.
What do people take Retatrutide / Cagrilintide for?
Weight loss.
Should I talk to a physician about Retatrutide / Cagrilintide?
If you are considering it, or already using it, a physician can look at your history, your labs and your goals, and at what else might explain what you are hoping to change. At Aether Medicine in King of Prussia, near Philadelphia, or by video for patients in Pennsylvania.
Further reading
- Jastreboff AM, et al. Triple-Hormone-Receptor Agonist Retatrutide for Obesity - A Phase 2 Trial. N Engl J Med. 2023. pubmed.ncbi.nlm.nih.gov/37366315/
- Jastreboff AM, et al. Retatrutide, a Triple Hormone Receptor Agonist, for Treatment of Obesity. N Engl J Med. 2026. pubmed.ncbi.nlm.nih.gov/42814954/
- Garvey WT, et al. Coadministered Cagrilintide and Semaglutide in Adults with Overweight or Obesity. N Engl J Med. 2025. pubmed.ncbi.nlm.nih.gov/40544433/
Educational information only, not medical advice. Reading this page does not create a physician-patient relationship.